General Information

  • ID:  hor001600
  • Uniprot ID:  P41870
  • Protein name:  FMRF-amide
  • Gene name:  NA
  • Organism:  Cornu aspersum (Brown garden snail) (Helix aspersa)
  • Family:  FARP (FMRFamide related peptide) family
  • Source:  animal
  • Expression:  Central nervous system.
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  Cornu (subgenus), Cornu (genus), Helicidae (family), Helicoidea (superfamily), Helicina, Stylommatophora (order), Eupulmonata (superorder), Panpulmonata, Euthyneura, Heterobranchia (subclass), Gastropoda (class), Mollusca (phylum), Lophotrochozoa, Spiralia, Protostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
  • GO MF:  NA
  • GO BP:  GO:0007218 neuropeptide signaling pathway
  • GO CC:  GO:0005576 extracellular region

Sequence Information

  • Sequence:  FMRF
  • Length:  4(206-209)
  • Propeptide:  MTSLCLTIAPAVLSLICLSSYGWAEDNNGIHTLDDGDNDPFFRHNRQFYRFGRAFVPLWDNADDSLVRKNLLTHWSEFPLSPALSSSDVFSRNSRQFYRFGRSYPPYQDKRFLRFGRSHQPDIDEYLQALNSDQALYRKRRSEDGDSKEDGLNRVARSADANQQSKNTQSNKFGKDLQKRETKKEKLNANDDLEILSNEDDLEKKFMRFGKRFMRFGRGDEDESYDKRFMRFGKSLRHDQEFEKRFMRFGKRFMR
  • Signal peptide:  MTSLCLTIAPAVLSLICLS
  • Modification:  T4 Phenylalanine amide
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  Can function as both cardioregulatory hormones and transmitters and may regulate cardiovascular function.
  • Mechanism:  NA
  • Cross BBB:  NA
  • Target:  NA
  • Target Unid:  NA
  • IC50: NA
  • EC50: NA
  • ED50: NA
  • kd: NA
  • Half life: NA

Structure

  • Disulfide bond:  NA
  • Structure ID:  AF-P41870-F1(AlphaFold_DB_ID)

  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
    •    hor001600_AF2.pdbhor001600_ESM.pdb

Physical Information

Mass: 65343 Formula: C29H41N7O5S
Absent amino acids: ACDEGHIKLNPQSTVWY Common amino acids: F
pI: 10.55 Basic residues: 1
Polar residues: 0 Hydrophobic residues: 2
Hydrophobicity: 75 Boman Index: -661
Half-Life: 1.1 hour Half-Life Yeast: 3 min
Half-Life E.Coli: 2 min Aliphatic Index 0
Instability Index: -1135 Extinction Coefficient cystines: 0
Absorbance 280nm: 0

Literature

  • PubMed ID:  1980513
  • Title:  Seven FMRFamide-related and two SCP-related cardioactive peptides from Helix.